Research

Consultancy Assignments undertaken
 
S.No.
Investigator/
Co-investigators
Name of the
Industry
Name of Project
Project
performed
 year
01
Dr.N.J.Patel, Dr.S.S.Pancholi
Dr. Rameshvar
M/s Fiberich Baroda
Determination of Glycemic Index and Nutritional value of its high fiber donuts
2007-08
02
Dr.S.S.Pancholi
Dr. Rameshwar
Vasa
 Pharmachem,
Ahmedabad
Preparation and submission of
CTD-DMF of excipients
2007-08
03
Dr.S.S.Pancholi,
Dr. Rameshwar
Vasa
Pharmachem,
Ahmedabad
Preparation and submission of
CTD-DMF of Eight APIs
May 2008
04
Dr.N.J.Patel,
Dr.Rameshvar Patel, Mr.N.R.Kanzariya
Ethicare Clinical
Services
Sub-acute toxicity study of
levitiracetum on wistar rats
Feb-March
2010
05
Dr.N.J.Patel,
Dr.Rameshvar Patel, Mr.N.R.Kanzariya
Ethicare Clinical
Services
Sub-acute toxicity study of
levitiracetum on swiss albino
mice
Feb-March
2010
06
Dr.N.J.Patel,
Dr.Rameshvar Patel, Mr.N.R.Kanzariya
Ethicare Clinical
Services
Sub-acute toxicity study of
Ertapenam on wistar rats
April –May
2010
07
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Ethicare Clinical
Services
Sub-acute toxicity study of
Ertapenam on swiss albino mice
April –May
2010
08
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Ethicare Clinical
Services
Skin sensitization study In guinea
Pigs (maximization test) of 
infusion set
December 2010
09
 
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Ethicare Clinical
Services
Test for interaction with blood
(prothrombin time test)
December 2010
10
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Ethicare Clinical
Services
Sub-Acute Intravenous Toxicity
Study of Amphotericin B
Liposome for Injection on Swiss
Albino Mice
 
December 2010
11
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Mr. Nilesh Patel
Mr Pankaj Tripathi
Ethicare Clinical
Services
Acute Intraperitoneal Toxicity
Study of Fomepizole API on
Swiss Albino Mice
December 2010
12
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Mr. Nilesh Patel
Mr Pankaj Tripathi
Ethicare Clinical
Services
Acute Oral Toxicity Study of
Fomepizole API on Swiss
Albino Mice
December 2010
13
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Mr. Nilesh Patel
Mr Pankaj Tripathi
Ethicare Clinical
Services
Acute Oral Toxicity Study of
Fomepizole API on Wistar Rats
December 2010
14
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Mr. Nilesh Patel
Mr Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Intravenous Toxicity
Study of Fomepizole Injection on
Swiss Albino Mice
December 2010
15
Dr.N.J.Patel,
Dr.Rameshvar,  Mr.N.R.Kanzariya
Mr. Nilesh Patel
Mr Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Intravenous Toxicity
Study of Fomepizole Injection on
Wistar Rats
December 2010
16
Dr.N.J.Patel,
Dr.Rameshvar, 
Mr. N.R.Kanzariya
Mr. Nilesh Patel
Mr Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Oral Toxicity Study
of Fomepizole API on Swiss
Albino Mice
December 2010
17
Dr.N.J.Patel,
Dr.Rameshvar, 
Mr. N.R.Kanzariya
Mr. Nilesh Patel
Mr Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Oral Toxicity Study
Of Fomepizole API on Wistar
Rats
December 2010
18
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Acute Intravenous toxicity study of Tolperisone plus Diclofenac injection on wistar rats
December 2011
19
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Acute Intravenous toxicity study of Tolperisone plus Diclofenac injection on swiss albino mice
December 2011
20
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Acute Intramuscular toxicity study of Tolperisone plus Diclofenac injection on wistar rats
December 2011
21
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Acute Intramuscular toxicity study of Tolperisone plus Diclofenac injection on swiss albino mice
December 2011
22
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Intravenous toxicity study of Tolperisone plus Diclofenac injection on wistar rats
December 2011
23
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Intravenous toxicity study of Tolperisone plus Diclofenac injection on swiss albino mice
December 2011
24
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Intramuscular toxicity study of Tolperisone plus Diclofenac injection on wistar rats
December 2011
25
Dr.N.J.Patel,
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Ethicare Clinical
Services
Sub-Acute Intramuscular toxicity study of Tolperisone plus Diclofenac injection on swiss albino mice
December 2011
26
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
Astron Research
 Ltd., Ahmedabad
Bioavailability study of new drug formulations of Anticancer drugs
April-2013
27
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
UmaLaxmi Organics Pvt. Ltd.
Jodhpur
Acute Oral Toxicity study of SAFED MUSLI on Wistar Rats
August-2013
28
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
Dr. Pankaj Tripathi
UmaLaxmi Organics Pvt. Ltd.
Jodhpur
Sub-Acute Oral Toxicity study of SAFED MUSLI on Wistar Rats
September-October 2013
29
Dr. Nilesh Patel,
 
Vasu Research Centre, Vadodara
Evaluation Of Anti-diabetic Activity Of Wsf Coded Drug Using Hfd-stz Induced Type 2 Diabetic Rat Model
August 2013-February-2014
30
Dr. Nilesh Patel,
Dr. Pankaj Tripathi
Vasu Research Centre, Vadodara
Acute toxicity study and Evaluation of anti-osteoporotic activity of Bonton capsule on ovariectomized rat model
August 2013-February-2014
31
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
 
Vasu Research Centre, Vadodara models
Effect of ural syrup on renal tubular acidosis driven Urolithiasis in experimental models
August 2013-February-2014
32
Dr. Nilesh Patel,
Dr. N.R.Kanzariya,
 
Vasu Research Centre, Vadodara
 
Acute toxicity study and evaluation of In-vitro antispasmodic activity
of Caspa drops
August 2013-February-2014
33
Dr. Nilesh Patel,
Dr. Pankaj Tripathi
Dr. N.R.Kanzariya,
 
Vasa
 Pharmachem,
Ahmedabad
Preparation and submission of
CTD-DMF of excipients
2012-14
 
 
Preclinical Contract Research Organization (CRO)
Department of Pharmacology, S.K Patel College of Pharmaceutical Education & Research  is a Pre-clinical contract research organization (CRO) providing in vitro and in vivo efficacy studies for endocrinal, inflammatory, neurology and toxicology fields. Our approach and capability is aligned to a mechanistic development program. We offer pre clinical in vitro and in vivo assays that deliver important mechanistic data informing efficacy study design.
In addition to providing the traditional values of reproducibility, efficient timelines and quality reporting, our preclinical contract services are characterized with: 
               Custom study design and data interpretation by highly experienced scientists
               Collaborative approach during the scientific process to meet study objectives
               Capability to develop new models to fulfill unmet needs
 
Animal House:
The department has a well designed and maintained separate central animal facility established with humidity, temperature control and air handling unit. Separate housing of rats, mice, guinea pigs and rabbits is created within the animal house. Usage of animal for experimental and research purpose are regularly monitored and approved by Institutional Animal Ethics Committee (IAEC) of S.K. Patel College of P’Ceutical Education & Research. The animals are purchased from a licensed & approved breeder as & when required in large number.
 
Pharmacology & Toxicology Laboratory:
Pharmacology laboratory is specially designed to carry out various in-vitro experiments on isolated organs, tissues and cells. Bioassays and evaluation of drugs by various animal models like analgesics, anti-inflammatory, antidiabetic, antihypertensive, antiasthmatic, antipsychotic and anticancer are carried out in this laboratory. Software based experiments are also taught as per CPCSEA guidelines.
Equipped laboratory is in position to carry out following studies:
In-vitro services:
1. Aldose Reductase inhibition using rats lens
2. PPAR-gamma agonistic assay
3. Anti-Stroke using PC12 cell line
4. Antidiabetic activity
5. Cytotoxicity studies
6. Antioxidant activity
7. Enzyme inhibitory activity
8. Chromosomal aberration assay
9. Ames test
10. Micronucleus assay
11. Hepato protective activity
 
In-vivo services:
1. Inflammation disease models: - General models of inflammation
                                                      - Allergic asthma in vivo model
                                                     - Arthritis in-vivo inflammation models
                                                     - Inflammatory Bowel Disease (IBD) in-vivo models
2. CNS models: - Cognition enhancer
                          - Antidepressant
                          - Anti-anxiety
                          - Sedative/hypnotics
                          - Anti convulsant
                          - Anti psychotics
3. Pain models: - Nociception pain models using hot plate and tail flick models  
                          - Neuropathic pain model- diabetic neuropathy
                         - Inflammatory pain model- carrageenan and formaldehyde
4. Ischemia reperfusion injury model: - stroke and Myocardial Ischemia
5. Endocrine disease model: - single dose of STZ treated Type-I diabetes model
                                              - STZ+ HFD model for Type-II diabetes
                                              - HFD model for obesity
6. CVS models: -Coronary artery ligation model for myocardial infarction
                                         - DOCA-salt induced hypertension in rats
                                         - Fructose induced hypertension in rats
                                         - Two Kidney One Clip model for hypertension
7. Toxicity studies: - Single, repeated dose toxicity study
                                - Dermal Irritation toxicity study
                                - Mutagenicity
                                               - Genotoxicity
 
We have also expertise to prepare protocol for clinical studies viz. Bioavailability and Bioequivalence studies and Drug Master File/Dossier for excipients and/or drug substance according to different regulatory agencies